Author

R. Riek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 6 Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:protein folding & dynamics· 7 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:protein structure· 2

Frequent Co-Authors

C. Eichmann· 4 shared J. Greenwald· 3 shared A. Olerinyova· 2 shared D. Ashkinadze· 2 shared H. Kadavath· 2 shared L. Frey· 2 shared P. Kukura· 2 shared R. Bomba· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

C. Eichmann

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The potential role of liquid-liquid phase separation in the cellular fate of the compartments for unconventional protein secretion

L. F. S. Mendes, C. G. Oliveira, M. D. Silva, S. K. Rout, R. Riek, A. J. Costa-Filho

This study investigates how liquid-liquid phase separation facilitates the formation of a vesicular-like compartment for unconventional protein secretion in yeast under starvation stress.

bioRxiv · Dec 19, 2023Biophysics

On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation

L. Frey, D. Ghosh, B. M. Qureshi, D. Rhyner, R. Guerrero-Ferreira, A. Pokharna, W. Kwiatkowski, T. Serdiuk, P. Picotti, R. Riek, J. Greenwald

This study investigates how pH affects α-synuclein fibril polymorphism and shows that secondary nucleation is not polymorph-specific, revealing new polymorphs at pH 7.0.

bioRxiv · Jun 25, 2023Biophysics

Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, 4-repeat/full-length tau and alpha-synuclein

J. Sobek, J. Li, B. F. Combes, J. A. Gerez, P. K. Nilsson, M. T. Henrich, F. F. Geibl, K. Shi, A. Rominger, W. H. Oertel, R. M. Nitsch, A. Nordberg, H. Agren, R. Riek, R. Ni

The paper develops an SPR-based method to characterize small molecule ligands binding to amyloid-beta, tau, and alpha-synuclein fibrils, identifying multiple binding sites.

bioRxiv · Mar 12, 2023 · PreprintPharmacology & Toxicology

Multi-Dimensional Structure and Dynamics Landscape of Proteins in Mammalian Cells Revealed by In-cell NMR

H. Kadavath, N. Prymaczok, C. Eichmann, R. Riek, J. Gerez

The paper uses in-cell NMR to study protein structure and dynamics in mammalian cells, finding evidence of multiple structural states and transient interactions.

bioRxiv · Sep 20, 2022Cell Biology

A conserved mechanism regulates reversible amyloids via pH-sensing regions

G. Cereghetti, V. M. Kissling, L. M. Koch, A. Arm, P. Afanasyev, M. Linsenmeier, C. Eichmann, J. Zhou, Y. Cao, D. M. Pfizenmaier, S. Kroschwald, T. Wiegand, R. Cadalbert, D. Boehringer, R. Mezzenga, , M. Peter

This study identifies a conserved mechanism by which pH-sensing regions regulate reversible amyloid formation in pyruvate kinase across yeast and human cells.

bioRxiv · Mar 21, 2022 · PreprintCell Biology

Atomic resolution Protein Allostery from the multi-state Structure of a PDZ Domain

D. Ashkinadze, H. Kadavath, C. N. Chi, M. Friedmann, D. Strotz, P. Kumari, M. Minges, R. Cadalbert, S. KÖnigl, P. Güntert, B. Vogeli, R. Riek

The paper determines multi-state structures of the PDZ2 domain using NMR to study protein allostery and conformational changes.

bioRxiv · Nov 23, 2021Biophysics

Mass Photometry of Membrane Proteins

A. Olerinyova, A. Sonn Segev, J. Gault, C. Eichmann, J. Schimpf, A. H. Kopf, L. S. P. Rudden, D. Ashkinadze, R. Bomba, J. Greenwald, M. T. Degiacomi, J. A. Killian, T. Friedrich, R. Riek, W. B. Struwe, P. Kukura

This study uses mass photometry to analyze membrane proteins and mimetic systems, revealing structural insights and improving nanodisc assembly characterization.

bioRxiv · Feb 28, 2020Biophysics

Cooperative induction of ordered peptide and fatty acid aggregates

R. Riek, J. Greenwald, W. Kwiatkowski, R. Bomba

This study investigates how amyloidogenic peptides and fatty acids form cooperative aggregates, expanding the phase space of both molecules and suggesting a physical link relevant to the origin of cellular life.

bioRxiv · May 28, 2018Biophysics

Quantitative mass imaging of single molecules in solution

G. Young, N. Hundt, D. Cole, A. Fineberg, J. Andrecka, A. Tyler, A. Olerinyova, A. Ansari, E. G. Marklund, M. P. Collier, S. A. Chandler, O. Tkachenko, J. Allen, M. Crispin, N. Billington, , P. Kukura

This paper introduces a method to mass-image single biomolecules in solution with high precision and resolution, enabling the study of molecular interactions and assemblies.

bioRxiv · Dec 6, 2017Biophysics