Author

R. Sitcheran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. P. West· 2 shared A. D. Winters· 1 shared B. R. Hoffmann· 1 shared C. G. Martinez· 1 shared C. L. Cannon· 1 shared D. W. Lee· 1 shared J. J. VanPortfliet· 1 shared J. Keeney· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

A. P. West

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Author profile →

3 papers

Recent·Most cited

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

J. J. VanPortfliet, Y. Lei, M. Ramanathan, C. G. Martinez, J. Wong, T. J. Stodola, B. R. Hoffmann, K. Pflug, R. Sitcheran, S. C. Kneeland, S. A. Murray, P. J. McGuire, C. L. Cannon, A. P. West

This study identifies caspase-11 as a driver of macrophage hyperinflammation in Polg-related mitochondrial disease models, linking IFN-I signaling to exacerbated infection outcomes.

bioRxiv · May 11, 2024Immunology

NF-κB-Inducing Kinase (NIK) Governs the Mitochondrial Respiratory Capacity, Differentiation, and Inflammatory Status of Innate Immune Cells

J. N. Keeney, A. D. Winters, R. Sitcheran, A. P. West

This study shows that NIK regulates mitochondrial function, differentiation, and inflammatory responses in innate immune cells, linking metabolic changes to immune cell behavior.

bioRxiv · Aug 6, 2022Immunology

NF-κB-Inducing Kinase Maintains Mitochondrial Efficiency and Systemic Metabolic Homeostasis

K. M. Pflug, D. W. Lee, J. Keeney, R. Sitcheran

This study shows NIK maintains mitochondrial efficiency and systemic metabolic homeostasis, with NIK KO mice exhibiting increased glucose utilization and glycolysis under metabolic stress.

bioRxiv · Aug 26, 2021Physiology