Author

M. Ramanathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

P. Khavari· 2 shared W. Miao· 2 shared A. Gupta· 1 shared A. Lane· 1 shared A. P. Lane· 1 shared A. P. West· 1 shared A. Pekosz· 1 shared A. Saraswathula· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

P. Khavari

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma

F. T. Zamuner, S. Gunti, G. J. Starrett, F. Faraji, T. Toni, A. Saraswathula, K. Vu, A. Gupta, Y. Zhang, D. Faden, M. E. Bryan, T. Guo, N. R. Rowan, M. Ramanathan, A. P. Lane, , N. R. London

This study identifies molecular differences between HPV-associated and HPV-independent SNSCC, showing HPV drives tumorigenesis and suggesting YAP/TAZ and PI3K inhibition as therapeutic targets.

bioRxiv · Jun 17, 2024Cancer Biology

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

J. J. VanPortfliet, Y. Lei, M. Ramanathan, C. G. Martinez, J. Wong, T. J. Stodola, B. R. Hoffmann, K. Pflug, R. Sitcheran, S. C. Kneeland, S. A. Murray, P. J. McGuire, C. L. Cannon, A. P. West

This study identifies caspase-11 as a driver of macrophage hyperinflammation in Polg-related mitochondrial disease models, linking IFN-I signaling to exacerbated infection outcomes.

bioRxiv · May 11, 2024Immunology

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

M. Chen, A. Pekosz, J. Villano, W. Shen, R. Zhou, H. Kulaga, Z. Li, S. E. Beck, K. W. Witwer, J. Mankowski, M. Ramanathan, N. Rowan, A. Lane

This study examines how SARS-CoV-2 variants infect nasal and olfactory tissues, showing differences in tropism, immune response, and regeneration across age groups.

bioRxiv · Apr 12, 2022Pathology

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

J. Meyers, M. Ramanathan, R. Shanderson, L. Donohue, I. Ferguson, M. Guo, D. Rao, W. Miao, D. Reynolds, X. Yang, Y. Zhao, Y.-Y. Yang, Y. Wang, P. Khavari

This paper identifies host proteins proximal to 17 SARS-CoV-2 viral proteins, revealing mechanisms of antiviral signaling disruption and host translation inhibition.

bioRxiv · Feb 23, 2021Microbiology

SARS-CoV-2 B.1.1.7 and B.1.351 Spike variants bind human ACE2 with increased affinity

P. Khavari, M. Ramanathan, I. D. Ferguson, W. Miao

This study measures the binding affinity of SARS-CoV-2 B.1.1.7 and B.1.351 Spike variants to human ACE2 using MST, finding increased binding for both variants compared to the original SARS-CoV-2 RBD.

bioRxiv · Feb 22, 2021Pathology