D. Xiao

A functional medicine and food homology composition discovery based on disease-related target and data mining against cardiac remodeling

This study identifies β-ecdysterone as a functional compound that counteracts cardiac remodeling by enhancing NRF2, revealing cross-talk between cardiac remodeling and neuromodulation.

Universal inverse modelling of point spread functions for SMLM localization and microscope characterization

This paper introduces uiPSF, a toolbox to infer accurate PSF models from microscopy data for improved SMLM imaging and microscope characterization.

NGAL deficiency elicits Hemophilia-like bleeding and clotting disorder

This study shows NGAL deficiency causes Hemophilia-like bleeding and clotting issues by enhancing coagulation and suppressing antithrombin.

Large-FOV 3D localization microscopy by spatially variant point spread function generation

This paper introduces PPG3D, a PCA-based PSF generator for 3D localization microscopy, improving accuracy and speed for large FOV imaging.

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis

This study compares the tumorigenic potential of MOLT4 and JURKAT T-ALL cell lines, finding that CCR9 overexpression enhances cholesterol biosynthesis and promotes T-ALL progression.

Deep Learning Enhanced Fast Fluorescence Lifetime Imaging with A Few Photons

This paper introduces a deep learning framework for fast fluorescence lifetime imaging under low-light conditions, achieving robust results with few photons per pixel.

Mesotrode: chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice.

Mesotrode enables chronic simultaneous mesoscale cortical imaging and subcortical/nerve spiking activity recording in mice, revealing functional connectivity and behavior-related neural networks.

MicroRNA-155 regulates osteogenesis and bone mass phenotype via targeting S1PR1 gene

This study shows miR155 inhibits osteogenesis and reduces bone mass by targeting S1PR1, suggesting miR155 inhibition could promote bone regeneration.

SMC1A facilitates gastric cancer cells proliferation, migration and invasion via promoting SNAI2 activated EMT

This study shows SMC1A promotes gastric cancer progression by enhancing SNAI2-driven EMT, suggesting it as a therapeutic target.

A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR

The paper develops a D-2-hydroxyglutarate biosensor using DhdR, which detects D-2-HG in biological samples with high specificity and sensitivity.

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

Tumor-stromal IL1β/ NFκB / ESE3 Signal Axis Drives Pancreatic Cancer Fibrosis, Chemoresistance, Prognosis

This study identifies an IL1β/NFκB/ESE3 signaling axis in pancreatic stellate cells that drives fibrosis, chemoresistance, and poor prognosis in pancreatic cancer.

A fluorescent L-2-hydroxyglutarate biosensor

The paper develops a fluorescent biosensor for L-2-hydroxyglutarate (L-2-HG) using LhgR, a transcription factor that recognizes L-2-HG, and demonstrates its application in monitoring L-2-HG levels in bacterial and human cells.

Negative effects characterization and comparative transcriptomics elucidation on the lag phase of an industrial S. cerevisiae under the corn stover hydrolysate stress

This study characterizes the negative effects of corn stover hydrolysate on industrial S. cerevisiae and identifies transcriptomic responses during the lag phase.

Remodeling gut microbiota by Streptococcus thermophilus 19 attenuates inflammation in septic mice

This study shows that S. thermophilus 19 reduces inflammation in septic mice by remodeling gut microbiota.

Novel regulators of nitric oxide signaling triggered by host perception in a plant pathogen

This study identifies FgANK1 and FgZC1 as key regulators of nitric oxide production and virulence in Fusarium graminearum during host recognition.

Influence of Organic Matrix and Cations on Bio-Methane Yield with Anthracite Methanogenic Consortium

The paper investigates how organic matrix and cation concentrations affect bio-methane yield using an anthracite methanogenic consortium, finding optimal cation levels and the inhibitory effect of Mg2+.

Primary Studies on the Effect of Microbially Coalbed Methane Enhancement in Suit in the Qinshui Basin

The paper investigates the effectiveness of microbial coalbed methane enhancement in the Qinshui Basin, showing increased methane production through biogasification in specific wells.