Author

R. Unckless

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 6 Microbiology· 2

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Research Focus:host-pathogen & immune response· 6 Organism:Drosophila· 5 Approach:experimental assay· 4 Approach:statistical model· 3 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

T. Hill· 4 shared A. Fehr· 1 shared A. Gupta· 1 shared A. Kamacioglu· 1 shared A. M. Darby· 1 shared B. Longdon· 1 shared B. Smith· 1 shared C. A. Miller· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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4 shared papersEvolutionary Biology

T. Hill

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Author profile →

8 papers

Recent·Most cited

A suite of selective pressures supports the maintenance of alleles of a Drosophila immune peptide

S. R. Mullinax, A. M. Darby, A. Gupta, P. Chan, B. Smith, R. Unckless

This study investigates the maintenance of diptericin A alleles in Drosophila by analyzing immune responses, sex-specific effects, and microbiome composition across different genotypes.

bioRxiv · Aug 18, 2023 · PreprintEvolutionary Biology

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

Y. M. Alhammad, S. Parthasarathy, R. Ghimire, J. J. O'Connor, C. M. Kerr, J. J. Pfannenstiel, D. Chanda, C. A. Miller, R. Unckless, S. Zuniga, L. Enjuanes, S. More, R. Channappanavar, A. Fehr

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

Ecological correlates of gene family size in a pine-feeding sawfly genome and across Hymenoptera

K. Vertacnik, D. Herrig, R. K. Godfrey, T. Hill, S. Geib, R. Unckless, D. Nelson, C. R. Linnen

The paper examines gene family evolution in a pine-feeding sawfly and across Hymenoptera, finding that gene family expansions are linked to ecological adaptation, while contractions are less common.

bioRxiv · Mar 14, 2021 · PreprintEvolutionary Biology

Rapid divergence of the copulation proteins in the Drosophila dunni group is associated with hybrid post-mating-prezygotic incompatibilities

T. Hill, H.-L. Rosales-Stephens, R. Unckless

The paper examines post-mating-prezygotic incompatibilities in Drosophila dunni group species and identifies rapid evolution of seminal fluid proteins as a potential cause.

bioRxiv · May 20, 2020Evolutionary Biology

Adaptation, ancestral variation and gene flow in a Sky Island Drosophila species

T. Hill, R. Unckless

This study examines the population history and adaptation of Drosophila innubila across mountain ranges, finding evidence of recent expansion and local adaptation in immune-related genes.

bioRxiv · May 14, 2020Evolutionary Biology

Recurrent evolution of two competing haplotypes in an insect DNA virus

T. Hill, R. Unckless

The paper studies coevolution between Drosophila and a DNA virus, identifying two viral haplotypes with differing titers and showing recurrent evolution due to selective pressures.

bioRxiv · May 14, 2020 · PreprintEvolutionary Biology

Efflux pumps in Chromobacterium species and their involvement in antibiotic tolerance and survival in a co-culture competition model

S. Benomar, K. C. Evans, R. Unckless, J. R. Chandler

This paper identifies two RND-family efflux pumps in Chromobacterium species that confer antibiotic resistance and enhance competitive survival in co-culture with Burkholderia thailandensis.

bioRxiv · Apr 16, 2019 · PreprintMicrobiology

Host-pathogen coevolution increases genetic variation in susceptibility to infection

E. M. Duxbury, J. P. Day, D. Maria Vespasiani, Y. Thüringer, I. Tolosana, S. C. Smith, L. Tagliaferri, A. Kamacioglu, I. Lindsley, L. Love, R. Unckless, F. M. Jiggins, B. Longdon

The paper shows that coevolved pathogens increase genetic variation in host susceptibility to infection compared to novel pathogens.

bioRxiv · Nov 26, 2018Evolutionary Biology