Author

R. Channappanavar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 6 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. More· 5 shared R. Ghimire· 4 shared D. Chanda· 3 shared C. M. Kerr· 2 shared J. J. O'Connor· 2 shared J. J. Pfannenstiel· 2 shared M. Selvaraj· 2 shared R. Shrestha· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersImmunology

S. More

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Author profile →

6 papers

Recent·Most cited

Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection

C. M. Kerr, J. J. Pfannenstiel, Y. M. Alhammad, J. J. O'Connor, R. Ghimire, R. Shrestha, R. Khattabi, P. Saenjamsai, S. Parthasarathy, P. R. McDonald, P. Gao, D. K. Johnson, S. More, A. Roy, R. Channappanavar, A. R. Fehr

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

bioRxiv · Jan 3, 2024 · PreprintMicrobiology

Klebsiella pneumoniae Co-infection Leads to Fatal Pneumonia in SARS-CoV-2-infected Mice

C. Villalva, G. Patil, S. Narayanan, D. Chanda, R. Ghimire, T. Snider, A. Ramachandran, R. Channappanavar, S. More

This study shows that co-infection with SARS-CoV-2 and Klebsiella pneumoniae in mice leads to severe pneumonia and higher mortality.

bioRxiv · Jul 28, 2023Immunology

Toll-like receptor 7 (TLR7)-mediated antiviral response protects mice from lethal SARS-CoV-2 infection

R. Ghimire, R. Shrestha, R. Amaradhi, T. Patton, C. Whitley, D. Chanda, L. Liu, S. More, T. Ganesh, R. Channappanavar

This study shows that TLR7 signaling protects mice from lethal SARS-CoV-2 infection by enhancing antiviral responses and reducing inflammation.

bioRxiv · May 8, 2023Immunology

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

Y. M. Alhammad, S. Parthasarathy, R. Ghimire, J. J. O'Connor, C. M. Kerr, J. J. Pfannenstiel, D. Chanda, C. A. Miller, R. Unckless, S. Zuniga, L. Enjuanes, S. More, R. Channappanavar, A. Fehr

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

Time-Dependent Increase in Susceptibility and Severity of Secondary Bacterial Infection during SARS-CoV-2 Infection

A. P. Smith, E. Williams, T. Plunkett, M. Selvaraj, L. Lane, L. Zalduondo, Y. Xue, P. Vogel, R. Channappanavar, C. Jonsson, A. Smith

This study shows that SARS-CoV-2 infection increases susceptibility and severity of secondary bacterial infection in mice, with time-dependent effects on immune responses and lethality.

bioRxiv · Feb 28, 2022 · PreprintMicrobiology

Effective interferon (IFN)-lambda treatment regimen to control lethal MERS-CoV infection in mice

R. Dijkman, M. Selvaraj, H. H. Gad, S. More, R. Hartmann, S. Perlman, V. Thiel, R. Channappanavar

This study identifies an effective two-dose IFN-lambda regimen that protects mice from lethal MERS-CoV infection by reducing viral load and inflammation.

bioRxiv · May 26, 2021 · PreprintImmunology