J. R. Chandler

Characterization of natural product inhibitors of quorum sensing in Pseudomonas aeruginosa reveals competitive inhibition of RhlR by ortho-vanillin

This study evaluates benzaldehyde derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa, identifying ortho-vanillin as a competitive inhibitor of RhlR.

Regulation of an antibiotic resistance efflux pump by quorum sensing and a TetR-family repressor in Chromobacterium subtsugae

This study investigates how Chromobacterium subtsugae regulates antibiotic resistance genes through quorum sensing and a TetR-family repressor, showing independent modulation by CviR and CdeR.

Tobramycin adaptation alters the antibiotic susceptibility of Pseudomonas aeruginosa quorum sensing-null mutants

This study shows that a mutation in fusA1 enhances tobramycin resistance in lasR-null Pseudomonas aeruginosa mutants through interactions with the MexXY efflux pump and ArmZ regulator.

Cross-species activation of hydrogen cyanide production by a promiscuous quorum-sensing receptor promotes Chromobacterium subtsugae competition in a dual-species model

This study shows that promiscuous quorum-sensing receptors in Chromobacterium subtsugae allow cross-species activation of hydrogen cyanide production, giving it a competitive advantage in a dual-species model.

Tobramycin adaptation enhances policing of social cheaters in Pseudomonas aeruginosa

This study shows tobramycin suppresses lasR mutants in Pseudomonas aeruginosa by directly targeting cheaters and selecting for mutations that enhance pyocyanin-mediated policing.

Burkholderia thailandensis methylated hydroxy-alkylquinolines: biosynthesis and antimicrobial activity in co-culture experiments

This study identifies N-oxidated methyl-alkenylquinolines (HMAQ-NOs) as antimicrobial compounds produced by Burkholderia thailandensis, showing they are 50-fold more active than their non-oxidized counterparts against Bacillus subtilis.

Efflux pumps in Chromobacterium species and their involvement in antibiotic tolerance and survival in a co-culture competition model

This paper identifies two RND-family efflux pumps in Chromobacterium species that confer antibiotic resistance and enhance competitive survival in co-culture with Burkholderia thailandensis.

The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen

This study shows that the C. elegans protein PBO-1 regulates intestinal pH, which is critical for pathogen defense through reactive oxygen species production.