Adam Burkholder

Shared trans-ancestry architecture of HLA-mediated disease risk in the All of Us Research Program

The paper analyzes HLA variation across six ancestry groups in the All of Us Research Program to identify HLA-phenotype associations and assess ancestry-specific genetic architecture.

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast

The paper shows that a hypomorphic mutation in RPA subunit rfa1-t33 in yeast enhances APOBEC-induced mutagenesis and alters mutation spectra.

Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing

This study uses Duplex Sequencing to detect DNA replication errors and mutations in E. coli, identifying in vivo mutations in mutL and mutT strains and revealing context effects and strand bias.

NF-Y Controls Fidelity of Transcription Initiation at Gene Promoters Through Maintenance of the Nucleosome-Depleted Region

This study shows NF-Y maintains nucleosome-depleted regions at promoters to ensure accurate transcription initiation, preventing aberrant gene expression.

The kinetics of pre-mRNA splicing in the Drosophila genome: influence of gene architecture

The paper measures splicing rates genome-wide in Drosophila to understand how gene architecture affects splicing efficiency and accuracy.