Author

Leah Kelly

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jeffrey M. FriedmaniD· 3 shared Aldana M. AntoniazziiD· 1 shared Alexandre Moura‐AssisiD· 1 shared Anduena Toci· 1 shared Anoj IlangesiD· 1 shared Bora Lee· 1 shared Bowen TaniD· 1 shared Chris B. SchafferiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Jeffrey M. FriedmanORCID

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3 papers

Recent·Most cited

Single-cell multi-omics identify OTP and NOVA1 as regulators of leptin action in hypothalamic feeding circuits

Han L. Tan, Yuqi Tan, Jenelys Ruiz-Ortiz, Matt Paul, Zhaoyu Han, Leah Kelly, Anduena Toci, Kaja Plucinska, Yoko Tajima, Rani Shiao, Bora Lee, Anoj Ilanges, Robert B Darnell, Paul Cohen, Jeffrey M. Friedman

This study uses single-cell multi-omics to identify OTP and NOVA1 as key regulators of leptin action in hypothalamic feeding circuits, revealing cell-type-specific transcriptional and regulatory changes.

bioRxiv · Nov 6, 2026 · PreprintNeuroscience

Cellular and Molecular Basis of Leptin Resistance

Bowen Tan, Kristina Hedbacker, Leah Kelly, Zhaoyue Zhang, Alexandre Moura‐Assis, Ji‐Dung Luo, Joshua D. Rabinowitz, Jeffrey M. Friedman

The paper identifies mTOR activation in POMC neurons as a key mechanism causing leptin resistance in diet-induced obese mice.

Cell Metabolism · Mar 1, 2025Peer-reviewedNeuroscience

Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

Santiago René Unda, Lisa E. Pomeranz, Roberta Marongiu, Xiaofei Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, George Vaisey, Putianqi Wang, Jonathan P. Dyke, Edward K. Fung, Logan Grosenick, Rick T. Zirkel, Aldana M. Antoniazzi, Sofya Norman, , Michael G. Kaplitt

This paper develops magnetogenetic tools to bidirectionally regulate specific neuronal circuits in vivo using magnetic fields and shows their efficacy in motor control and Parkinson's models.

Science Advances · Oct 9, 2024Peer-reviewedNeuroscience