Author

Matthew Demers

Broad InstituteORCID 0000-0002-4103-9812Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Beth StevensiD· 3 shared Matthew B. JohnsoniD· 3 shared Nader MorshediD· 3 shared Jordan L. DomaniD· 2 shared Morgan ShengiD· 2 shared Adam J. GrangeriD· 1 shared Alexandra E. GouldiD· 1 shared Ana Geller· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Beth StevensORCID

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Author profile →

3 papers

Recent·Most cited

Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency in vitro but has limited impact in vivo

Saša Jereb, Lia R. D’Alessandro, Nader Morshed, Margery Chen, Rafaela Sartore, Zengpeng Han, Jordan E. McKinney, Pamela P. Brauer, John W. Harvey, Matthew Demers, Dara Cuffe, Raphael Rakosi-Schmidt, Luira Leite, Youtong Huang, Qingxia Zheng, , Benjamin E. Deverman

The paper compares microglia-targeted AAVs, finding that capsid choice affects in vitro efficiency but not in vivo transduction when using specific promoters.

bioRxiv · Aug 5, 2026 · PreprintNeuroscience

iAstrocytes model cytokine influences on complement expression and neuronal network synchronization.

Nader Morshed, Matthew Demers, Ana Gonzalez‐Ramos, Henna Jäntti, Jordan L. Doman, Sean D'Souza, Letian Li, Adam J. Granger, Matthew B. Johnson, Beth Stevens

The paper develops a method to generate functional induced astrocytes (iAstrocytes) from human pluripotent stem cells and shows their role in promoting synchronized neuronal network activity.

bioRxiv · Jun 5, 2026 · PreprintNeuroscience

The G-protein coupled receptor GPR34 maintains the homeostatic state of microglia and restrains the disease-associated microglial response in an Alzheimers disease model

Ana Geller, Min Jee Kwon, Sean Simmons, Qihong Xu, William E. Martenis, Jordan L. Doman, Sahana Natarajan, Katherine J. Stalnaker, Jixiang Zhang, Xian Adiconis, Trang Nguyen, Matthew Demers, Donovan L. Batzli, Antia Valle-Tojeiro, Christy Biji, , Prabhat S. Kunwar

This study shows that GPR34 maintains microglial homeostasis and limits disease-associated microglial responses in Alzheimer's disease models.

bioRxiv · Nov 26, 2025 · PreprintNeuroscience