Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche
Sunny Z. Wu, Ryan S. Lane, Christopher Davidson, Ashley Byrne, Giulia Protti, Inés Marín, Endi K. Santosa, Alberto Guarnieri, Brandon D. Kayser, Hejin Huang, Katherine Williams, Matthew Fernandez, Jian Wei Jiang, Juan Zhang, Raymond Asuncion, , Shannon J. Turley
The paper identifies Grem1-expressing fibroblastic reticular cells as a source of FLT3L that supports dendritic cell homeostasis and function in lymph nodes.
Nature Immunology · Nov 17, 2025Peer-reviewedImmunology