Jian Wei Jiang

gCoSRNA predicts coaxial stacking in RNA junctions using sequence and secondary structure, achieving high accuracy across multiple branch types.

The paper identifies Grem1-expressing fibroblastic reticular cells as a source of FLT3L that supports dendritic cell homeostasis and function in lymph nodes.

The paper shows IRF2 degradation by IRF1 during immune responses enhances ISG transcription, revealing a regulatory circuit between IRF1 and IRF2 in innate immunity.

This paper introduces fluorescent protein-based ticker tapes (FPTT) to record transcriptional histories in single cells, demonstrating their use in tracking signaling dynamics in neurons and T-cells.

This study identifies spatially organized cDC1-T cell clusters within tumors as critical for enhancing CTL-mediated tumor rejection through local costimulation.

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.

This study shows that GPR158 in pyramidal neurons affects social novelty behavior in mice by modulating synaptic transmission and glutamate vesicle density in the medial prefrontal cortex.