Author

Rebecca Lee

The Francis Crick Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Abbey M. ButleriD· 1 shared Ambrosius P. SnijdersiD· 1 shared Andrew A. WangiD· 1 shared Bluma J. LeschiD· 1 shared Delaney FarrisiD· 1 shared Eric FagerbergiD· 1 shared Gabriel A RusselliD· 1 shared Haoming YuiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Abbey M. ButlerORCID

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2 papers

Recent·Most cited

Complementary constraints in germ and immune cells shape evolution of gene regulation and phenotype

Kimberly Griffin, Kira Lynn Marshall, Gabriel A Russell, John Attanasio, Delaney Farris, Haoming Yu, Eric Fagerberg, Nivedita R. Iyer, Rebecca Lee, Kaelyn Sumigray, Nikhil S. Joshi, Andrew A. Wang, Bluma J. Lesch

The paper shows that humanized Traf6 promoter sequences in mice affect immune responses but not fertility, revealing distinct roles for germ and immune cells in gene regulatory evolution.

bioRxiv · Mar 30, 2026 · PreprintGenetics

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

Roman O Fedoryshchak, Magdalena Přechová, Abbey M. Butler, Rebecca Lee, Nicola O’Reilly, Helen R. Flynn, Ambrosius P. Snijders, Noreen Eder, Sila K. Ultanir, Stéphane Mouilleron, Richard Treisman

The paper identifies the molecular mechanism by which Phactr1/PP1 phosphatase achieves substrate specificity through structural and phosphoproteomic analysis.

eLife · Sep 25, 2020Peer-reviewedMolecular Biology