Author

Nicola O’Reilly

The Francis Crick InstituteORCID 0000-0002-4204-6491Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Ambrosius P. SnijdersiD· 2 shared Helen R. FlynniD· 2 shared Abbey M. ButleriD· 1 shared Alessandro CostaiD· 1 shared Andrea NansiD· 1 shared Andrew G. PurkissiD· 1 shared Andrew PowelliD· 1 shared Antoine ClaessensiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

Ambrosius P. SnijdersORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

Hugo Belda, David Bradley, Evangelos Christodoulou, Stephanie D. Nofal, Malgorzata Broncel, David T. Jones, Heledd M. Davies, M. Teresa Bertran, Andrew G. Purkiss, R. W. Ogrodowicz, Dhira Joshi, Nicola O’Reilly, Louise J. Walport, Andrew Powell, David House, , Moritz Treeck

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

Nature Microbiology · May 19, 2025Peer-reviewedMicrobiology

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

Roman O Fedoryshchak, Magdalena Přechová, Abbey M. Butler, Rebecca Lee, Nicola O’Reilly, Helen R. Flynn, Ambrosius P. Snijders, Noreen Eder, Sila K. Ultanir, Stéphane Mouilleron, Richard Treisman

The paper identifies the molecular mechanism by which Phactr1/PP1 phosphatase achieves substrate specificity through structural and phosphoproteomic analysis.

eLife · Sep 25, 2020Peer-reviewedMolecular Biology

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Torahiko L. Higashi, Patrik Eickhoff, Joana S. Sousa, Julia Locke, Andrea Nans, Helen R. Flynn, Ambrosius P. Snijders, George Papageorgiou, Nicola O’Reilly, Zhuo Angel Chen, Francis J. O’Reilly, Juri Rappsilber, Alessandro Costa, Frank Uhlmann

This study uses cryo-EM and biochemical experiments to reveal the mechanism of DNA entry into the cohesin ring, showing how ATP binding and hydrolysis regulate the process.

Molecular Cell · Aug 4, 2020Peer-reviewedMolecular Biology