Annexin A2 mediates RIG-I-like receptor responses to viral infection
Georgie Wray‐McCann, David Michalík, Alexandra L. McAllan, Linden J. Gearing, Roxanne Hsiang-Chi Liou, Nicole K. Campbell, Sarah Straub, Hani Hosseini Far, Antony Y. Matthews, Michelle D. Tate, Sophia Davidson, Roman Fisher, Carrie Bernecky, Jan Rehwinkel, Paul J. Hertzog, Natália G. Sampaio
This study identifies Annexin A2 as a critical mediator of RIG-I-like receptor responses to viral infection by promoting MDA5 oligomerization and enhancing interferon production.
bioRxiv · Oct 28, 2025 · PreprintImmunology