Local glycan engineering induces systemic antitumor immune reactions via antigen cross-presentation
Natália Rodrigues Mantuano, Michael T. Sandholzer, Emiel Rossing, Johan F. A. Pijnenborg, Andreas Zingg, Filip Filipsky, Ronja Wieboldt, Amanda Carlos Paulino, Isabelle V. M. Siqueira, Thomas Jan Boltje, Heinz Philipp Laubli
This study shows that local glycan engineering using AAV-delivered sialidases reduces tumor growth and enhances systemic antitumor immunity through improved cross-presentation and dendritic cell activation.
bioRxiv · May 7, 2026 · PreprintImmunology