Thomas Jan Boltje

Local glycan engineering induces systemic antitumor immune reactions via antigen cross-presentation

This study shows that local glycan engineering using AAV-delivered sialidases reduces tumor growth and enhances systemic antitumor immunity through improved cross-presentation and dendritic cell activation.

A new stress-response pathway in Mycobacterium tuberculosis

This study identifies a new stress-response pathway in Mycobacterium tuberculosis that produces GABA-trehalose under hypoxia and immune stress.

Identification of novel biomarkers for pyridoxine-dependent epilepsy using untargeted metabolomics and infrared ion spectroscopy - biochemical insights and clinical implications

The paper identifies novel biomarkers for pyridoxine-dependent epilepsy using metabolomics and infrared ion spectroscopy, showing their potential for newborn screening and clinical implications.