A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction
Deng Pan, Philippe D. Gascard, Joseph A. Caruso, Chira Chen‐Tanyolac, Veena Sangwan, Nicholas Bertos, Sophie Camilleri‐Broët, Julie Bérubé, Spyridon Oikonomopoulos, Michael K. Strasser, David L. Gibbs, Joanna Bons, Jordan B. Burton, Jacob Rose, Samah Shah, , Thea Dorothy Tlsty
The paper identifies a fibroblast state called STIF that drives YAP-dependent regenerative programs and (pre)malignancy through mechanotransduction in response to tissue injury.
bioRxiv · Jul 11, 2025 · PreprintCancer Biology