Mark E. Warchol

A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells

The paper constructs a cross-species single-cell transcriptomic atlas of hair cells across multiple vertebrates and identifies conserved and species-specific gene expression programs.

Persistence of vestibular function in the absence of glutamatergic transmission from hair cells

This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.

Injury-Induced Remodeling of Junctional Actin Bands in the Vestibular Maculae of Mice and Chicks: Implications for Sensory Regeneration

This study compares injury-induced changes in junctional actin bands in the utricles of mice and chicks, finding differences in actin cable thickness and supporting cell expansion that may relate to regenerative capacity.

Cisplatin drives mitochondrial dysregulation in sensory hair cells

This study shows cisplatin accumulates in hair cell mitochondria and causes dysregulation, linking mitochondrial dysfunction to cisplatin-induced hearing loss.

Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochondrial homeostasis and hair cell function

This study shows that prolonged dexamethasone exposure promotes lateral-line hair cell regeneration in zebrafish but impairs mitochondrial function and hair cell resilience to ototoxic stress.

Programmed cell death recruits macrophages into the developing mouse cochlea

This study investigates the relationship between programmed cell death in the cochlea and macrophage recruitment during development, finding that macrophages are not essential for tissue remodeling.

Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish

This study shows mechanical overstimulation causes acute injury and synapse loss in zebrafish neuromasts, but recovery occurs rapidly.

Macrophages respond rapidly to ototoxic injury of lateral line hair cells but are not required for hair cell regeneration