Author

David S. Perlin

Georgetown UniversityORCID 0000-0002-9503-3184Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Erika ShoriD· 2 shared Akanksha M. PandeyiD· 1 shared Ariel Alejandro AptekmanniD· 1 shared Carol A. NacyiD· 1 shared Caroline E Hayter· 1 shared Chang LiuiD· 1 shared Chi ZhangiD· 1 shared Christopher Quinteros· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Erika ShorORCID

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2 papers

Recent·Most cited

Candida glabrata replicating within macrophages experiences amino acid deprivation, DNA damage, and chromosome instability

Ariel Alejandro Aptekmann, Nathaly Cabrera, Melody C. Hayman, Ruth A. Watson, Joseph A. Stewart, Christopher Quinteros, Chang Liu, Caroline E Hayter, Mikhail V. Keniya, David S. Perlin, Juan Lucas Argueso, Erika Shor

This study shows that Candida glabrata replicating inside macrophages experiences amino acid deprivation, DNA damage, and chromosome instability, with mutations in RME1 enhancing its survival.

bioRxiv · Sep 15, 2025 · PreprintMicrobiology

Broad-Spectrum Activity and Mechanisms of Action of SQ109 on a Variety of Fungi

Satish R. Malwal, Rocio Garcia‐Rubio, Milena Kordalewska, Hoja P. Patterson, Chi Zhang, Jorge D. Calderin, Ruijie Zhou, Akanksha M. Pandey, Erika Shor, David S. Perlin, Nathan P. Wiederhold, Luis Ostrosky‐Zeichner, Rutilio A. Fratti, Carol A. Nacy, Eric Oldfield

This study evaluates SQ109's antifungal activity against sixteen fungal pathogens and identifies its mechanisms involving mitochondrial targeting and isoprenoid biosynthesis pathway inhibition.

ACS Infectious Diseases · May 14, 2025Peer-reviewedMicrobiology