Author

R. Jafari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

G. Mermelekas· 2 shared M. Stahl· 2 shared A. Audrey· 1 shared A. Beck· 1 shared A. Chalechale· 1 shared A. J. Helmboldt· 1 shared A. Jahangir· 1 shared A. Khadem· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

G. Mermelekas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Assessment of resting state structural-functional relationships in perisylvian region during the early weeks after birth

R. Namiranian, H. Abrishami Moghaddam, A. Khadem, R. Jafari, A. Chalechale

This study examines structural-functional relationships in the perisylvian region of neonates using combined metrics, finding that myelination is more strongly linked to functional connectivity and fALFF than morphology.

bioRxiv · Oct 26, 2023Bioengineering

Deep thermal proteome profiling for detection of proteoforms and drug sensitivity biomarkers

N. Kurzawa, M. Stahl, I. Leo, E. Kunold, I. Becher, A. Audrey, G. Mermelekas, W. Huber, A. Mateus, M. Savitski, R. Jafari

The paper uses thermal proteome profiling to detect proteoforms and drug sensitivity biomarkers in acute lymphoblastic leukemia cell lines.

bioRxiv · Jun 10, 2022 · PreprintBiochemistry

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia

S. A. Herbst, M. Vesterlund, A. J. Helmboldt, R. Jafari, I. Siavelis, M. Stahl, E. Schitter, N. Liebers, B. Brinkmann, F. Czernilofsky, T. Roider, P.-M. Bruch, M. Iskar, A. Kittai, Y. Huang, , Hu

The paper performs a proteogenomic analysis of chronic lymphocytic leukemia, identifies a new poor-prognosis subgroup (ASB-CLL) through proteomic profiling, and links it to clinical outcomes.

bioRxiv · Mar 1, 2022Cancer Biology

Tumor-targeted delivery of childhood vaccine recall antigens by attenuated Listeria reduces pancreatic cancer

B. C. Selvanesan, D. Chandra, W. Quispe-Tintaya, A. Jahangir, A. Patel, K. Meena, R. Alberto Alves Da Silva, M. Friedman, J. Li, S. Siddiqui, S. K. Libutti, Z. Yuan, A. Beck, L. Tesfa, W. Koba, , C. Gravekamp

This study shows that delivering a childhood vaccine antigen via attenuated Listeria improves immunotherapy for pancreatic cancer by converting cold tumors into hot tumors and enhancing T cell activity.

bioRxiv · Jun 4, 2021 · PreprintImmunology

Inhibition of the ubiquitin-proteasome system by a bioactivatable compound

T. A. Giovannucci, F. Salomons, M. Haraldsson, L. Elfman, M. Wickstrom, P. Young, T. Lundback, J. Eirich, M. Altun, R. Jafari, A.-L. Gustavsson, J. I. Johnson, N. Dantuma

The paper identifies CBK77, a bioactivatable compound that inhibits the ubiquitin-proteasome system by targeting NQO1, leading to cell death in cancer cells.

bioRxiv · Mar 16, 2021Cell Biology