Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response
R. Amin, A. Shukla, J. J. Zhu, S. Kim, P. Wang, S. Z. Tian, A. D. Tran, D. Paul, S. D. Cappell, S. Burkett, H. Liu, M. P. Lee, M. J. Kruhlak, J. E. Dwyer, R. M. Simpson, , K. W. Hunter
This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.
bioRxiv · Feb 5, 2020Cancer Biology