Author

S. D. Cappell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Akef· 1 shared A. D. Tran· 1 shared A. Nussenzweig· 1 shared A. Shukla· 1 shared A. V. Pankajam· 1 shared D. Paul· 1 shared D. R. Larson· 1 shared D. Zong· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Akef

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR

D. Zong, N. C. Koussa, J. A. Cornwell, A. V. Pankajam, M. Kruhlak, N. Wong, R. Chari, S. D. Cappell, A. Nussenzweig

This study maps the cellular response to WRN loss in MSI-H cancers, showing DNA damage accumulation and cell death, and suggests dual targeting of WRN and ATR as a therapeutic strategy.

bioRxiv · Jul 28, 2023Cancer Biology

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

R. Amin, A. Shukla, J. J. Zhu, S. Kim, P. Wang, S. Z. Tian, A. D. Tran, D. Paul, S. D. Cappell, S. Burkett, H. Liu, M. P. Lee, M. J. Kruhlak, J. E. Dwyer, R. M. Simpson, , K. W. Hunter

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

bioRxiv · Feb 5, 2020Cancer Biology

Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation

A. Akef, K. McGraw, S. D. Cappell, D. R. Larson

This study shows that the U2AF1-S34F mutation disrupts ribosome biogenesis and translation, leading to increased mRNA translation and myeloid malignancy.

bioRxiv · Dec 13, 2019Cancer Biology