M. P. Lee

Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

Metastasis-specific gene expression in autochthonous and allograft mouse mammary tumor models: stratificationand identification of targetable signatures

This study compares metastasis-specific gene expression in different mouse breast cancer models and identifies clinically targetable pathways involved in metastatic spread.

Multi-model preclinical platform predicts clinical response of melanoma to immunotherapy

The paper develops a preclinical platform using syngeneic mouse models to predict melanoma patient response to immunotherapy and identifies a melanocytic plasticity signature linked to treatment outcomes.

Melanoblast transcriptome analysis reveals novel pathways promoting melanoma metastasis

The paper analyzes the melanoblast transcriptome to identify genes involved in melanoma metastasis and discovers a 43-gene signature predictive of patient survival.

Aicardi-Goutieres Syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer

This study identifies Rnaseh2c as a metastasis susceptibility gene in breast cancer, independent of its enzymatic activity, and links it to T cell-mediated immune responses.