G. L. Hager

The mineralocorticoid receptor forms higher order oligomers upon DNA binding

This study shows that the mineralocorticoid receptor (MR) forms tetramers in the nucleoplasm and higher order oligomers upon DNA binding, differing from the glucocorticoid receptor (GR) in quaternary structure.

Epigenetic silencing by SMYD3 represses tumor intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.

This study identifies SMYD3 as an epigenetic regulator that suppresses the intrinsic interferon response in HPV-negative HNSCC, offering a potential strategy to enhance immunotherapy response.

Single-molecule tracking reveals two low-mobility states for chromatin and transcriptional regulators within the nucleus

This study uses single-molecule tracking and machine learning to identify two low-mobility states of chromatin and transcriptional regulators, showing dynamic interactions and switching between states.

The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities

This study identifies non-canonical dimerization modes of the glucocorticoid receptor ligand-binding domain through structural analysis and functional assays.

Power-law behaviour of transcription factor dynamics at the single-molecule level implies a continuum affinity model

The paper analyzes single-molecule tracking data of transcription factors and finds power-law distributions, suggesting a continuum affinity model rather than discrete binding states.

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.