Author

R. M. Simpson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. D. Tran· 1 shared A. Hurlstone· 1 shared A. Sassano· 1 shared A. Shukla· 1 shared B.-R. Wei· 1 shared C. Smith· 1 shared C. W. Wong· 1 shared C.-P. Day· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. D. Tran

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Author profile →

3 papers

Recent·Most cited

Fusion-negative rhabdomyosarcoma orthotopic tongue xenografts for study of invasion, intravasation and metastasis in live animals

S. M. Hammoudeh, Y. Ng, B.-R. Wei, T. Madsen, R. M. Simpson, R. Weigert, P. A. Randazzo

bioRxiv · Sep 21, 2023 · PreprintCancer Biology

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

V. Gopalan, C. W. Wong, R. Leshem, L. Owen, T. Vallius, Y. Shi, Y. Jiang, E. Perez-Guijarro, E. Wu, S. Chin, J. Ebersole, C. Smith, A. Sassano, M. Alves Constantino, M. J. Haley, , K. L. Marie

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

bioRxiv · Oct 14, 2022 · PreprintCancer Biology

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

R. Amin, A. Shukla, J. J. Zhu, S. Kim, P. Wang, S. Z. Tian, A. D. Tran, D. Paul, S. D. Cappell, S. Burkett, H. Liu, M. P. Lee, M. J. Kruhlak, J. E. Dwyer, R. M. Simpson, , K. W. Hunter

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

bioRxiv · Feb 5, 2020Cancer Biology