Author

M. J. Kruhlak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. D. Tran· 2 shared A. Shukla· 1 shared C. L. Sweeney· 1 shared D. F. Stroncek· 1 shared D. Paul· 1 shared D. S. Goldstein· 1 shared G. L. Hager· 1 shared H. L. Malech· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. D. Tran

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3 papers

Recent·Most cited

EWSR1's visual modalities are defined by its association with nucleic acids and RNA polymerase II

S. Sundara Rajan, V. J. Ebegboni, P. Pichling, K. R. Ludwig, T. L. Jones, R. Chari, A. D. Tran, M. J. Kruhlak, J. Loncarek, N. J. Caplen

This study identifies two visual modalities of EWSR1 in the nucleoplasm, both associated with nascent RNA, and shows EWSR1 foci localize to euchromatin and phosphorylated RNA polymerase II.

Molecular and Cellular Biology · Mar 20, 2024Peer-reviewedCell Biology

Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells

N. Tamaoki, S. Siebert, T. Maeda, N.-H. Ha, M. L. Good, Y. Huang, S. K. Vodnala, J. J. H. Mora, U. Naoya, J. F. Tisdale, C. L. Sweeney, U. Choi, J. Brault, S. Koontz, H. L. Malech, , R. Vizcardo

This study develops yolk sac-like organoids from hiPSCs to generate multipotent hematopoietic progenitor cells in a scalable and xeno-free system.

bioRxiv · Apr 25, 2021Cell Biology

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

R. Amin, A. Shukla, J. J. Zhu, S. Kim, P. Wang, S. Z. Tian, A. D. Tran, D. Paul, S. D. Cappell, S. Burkett, H. Liu, M. P. Lee, M. J. Kruhlak, J. E. Dwyer, R. M. Simpson, , K. W. Hunter

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

bioRxiv · Feb 5, 2020Cancer Biology