S. Buus

Profiling of linear B-cell epitopes against human coronaviruses in pooled sera sampled early in the COVID-19 pandemic

This study identifies linear B-cell epitopes against human coronaviruses using pooled sera from COVID-19 convalescents and pre-pandemic controls, revealing cross-reactivity patterns and epitope distribution across coronavirus proteins.

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.

Extraordinary peptide-binding mode of a songbird MHC class-I molecule suggests mechanism to counter pathogen immune evasion

The study determines the structure of a songbird MHC class I protein, Acar3, and identifies an unusual peptide-binding mode that may enhance immune responses against pathogens.

Antibodies to native gluten arise from cross-reactive B cells with implications for epitope spreading in celiac disease

The paper identifies a new native gluten epitope recognized by cross-reactive B cells in celiac disease, which may contribute to epitope spreading.

HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures

The paper examines HIV-specific CD8+ T-cells in tonsils, finding they exhibit TRM-like exhaustion signatures compared to blood, with differences in natural HIV controllers.

A systematic, unbiased mapping of CD8+ and CD4+ T cell epitopes in Yellow Fever vaccinees

The paper systematically identifies and validates CD8+ and CD4+ T cell epitopes in Yellow Fever vaccinees, revealing immunodominant responses and HLA restrictions with broad population coverage.

HLA-class II specificity assessed by high-density peptide microarray interactions

This study uses high-density peptide microarrays to assess HLA-class II specificity, generating large-scale peptide-MHC-II interaction data to improve prediction tools.

T cell responses induced by attenuated flavivirus vaccination are specific and show limited cross-reactivity with other flavivirus species.

This study shows that T cell responses to flavivirus vaccines are specific and have limited cross-reactivity with other flavivirus species.

Footprints of antigen processing boost MHC class II natural ligand binding predictions

This study develops MHC class II ligand binding predictors trained on naturally eluted peptides, showing improved performance by incorporating antigen processing rules.