S. C. Binder

The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease

This study identifies the SAVED domain of CalpL as a ring nuclease that cleaves cA4, revealing its role in regulating the CRISPR defense system.

Structural basis of Cdk7 activation by dual T-loop phosphorylation

This study reports the crystal structure of fully activated Cdk7/Cyclin H/Mat1 complex with dual T-loop phosphorylations, revealing their distinct roles in kinase activity and substrate recognition.

Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential

This study uses nanobodies to reveal GSDMD pore formation mechanism and shows their therapeutic potential in preventing pyroptosis.

Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria

This paper shows that Corynebacterium diphtheriae toxin activates NLRP1 inflammasome and pyroptosis in keratinocytes via ribotoxic stress response pathways.

Rate of immune complex cycling in follicular dendritic cell determines the extent of protecting antigen integrity and availability to germinal center B cells

The paper estimates immune complex cycling rates in follicular dendritic cells and shows how this affects antigen protection and germinal center dynamics.