Author

K. Govender

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Adamson· 2 shared A. Derache· 1 shared A. F. Vallejo· 1 shared A. J. C. Steyn· 1 shared A. Leslie· 1 shared A. Sigal· 1 shared B. Gosnell· 1 shared B. Truebody· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

J. Adamson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Accessing anti-HIV activity through the attenuation of USP18 activity: novel insights from molecular dynamic simulations, free-energy profiling, and multi-cellular inhibition assays

L. T. Sigauke, J. Bvunzawabaya, G. Le Bury, G. A. Dziwornu, S. Boliar, D. W. Gludish, D. G. Russell, K. Govender, G. Mugumbate, N. Chigorimbo-Murefu

This study explores using USP18 inhibition to achieve anti-HIV activity through molecular simulations, free-energy profiling, and multi-cellular assays, showing reversible non-competitive inhibition and potential for antiviral strategies.

bioRxiv · Jun 23, 2024 · PreprintImmunology

Mycobacterium tuberculosis senses host Interferon- gamma via the membrane protein MmpL10

M. Ahmed, J. S. Mackenzie, R. Krause, B. Truebody, L. B. Tezera, D. Garay-Baquero, A. F. Vallejo, K. Govender, J. Adamson, P. Elkington, A. J. C. Steyn, A. Leslie

This study shows Mycobacterium tuberculosis senses IFN-γ via MmpL10, increasing respiration and virulence, and enhances INH efficacy against persistent bacteria.

bioRxiv · Nov 12, 2021Microbiology

The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

G. Lustig, S. Cele, F. Karim, Y. Ganga, K. Khan, B. Gosnell, Y. Moosa, R. Harrichandparsad, S. Marais, R. Gupta, A. Derache, J. Giandhari, T. de Oliveira, K. Govender, J. Adamson, , A. Sigal

The paper investigates the origin of HIV in the CNS of ART-suppressed individuals and finds T cell-derived HIV that can lead to drug resistance.

bioRxiv · Mar 25, 2019 · PreprintMicrobiology