Author

S. Charlton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:human· 2 Organism:non-human primate· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

K. R. Bewley· 4 shared B. Hallis· 3 shared K. A. Ryan· 3 shared N. S. Coombes· 3 shared Y. Hall· 3 shared E. Brunt· 2 shared E. Rayner· 2 shared H. E. Humphries· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

K. R. Bewley

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86

S. Turner, G. Amirthalingam, D. Bailey, D. H. Barouch, K. R. Bewley, K. Brown, Y. R. Cao, Y.-W. Chan, S. Charlton, DOVE consortium, N. S. Coombes, B. Hallis, D. D. Ho, F. Jian, N. Lasrado, , D. J. Smith

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

bioRxiv · Mar 27, 2024 · PreprintImmunology

Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years

K. Bougiouri, S. G. Aninta, S. Charlton, A. Harris, A. Carmagnini, G. Piliciauskiene, T. R. Feuerborn, L. Scarsbrook, K. Tabadda, P. Blazevicius, H. G. Parker, S. Gopalakrishnan, G. Larson, E. A. Ostrander, E. K. Irving-Pease, , F. Racimo

This study imputes ancient dog and wolf genomes to analyze inbreeding history over 10,000 years, finding lower inbreeding in ancient populations and associations between low ROH regions and olfaction/immune genes.

bioRxiv · Mar 15, 2024Evolutionary Biology

Evaluation of the cross reactivity of neutralising antibody response in vaccinated human and convalescent hamster sera against SARS-CoV-2 variants up to and including JN.1 using an authentic virus neutralisation assay

N. S. Coombes, K. R. Bewley, Y. Le Duff, N. Alami-Rahmouni, K. A. Ryan, S. Kempster, D. Ferguson, E. R. Davies, T. M. Weldon, E. S. Cross, L. Smith, C. Norris, K. R. Rogers-Broadway, K. Lewandowski, S. Treagus, , S. G. P. Funnell

This study evaluates neutralising antibody responses in vaccinated humans and convalescent hamsters against SARS-CoV-2 variants up to JN.1 using an authentic virus neutralisation assay, finding increased resistance to JN.1 in vaccinated individuals and specific neutralisation patterns in hamsters.

bioRxiv · Oct 21, 2023 · PreprintCell Biology

Polysaccharide breakdown products drive degradation-dispersal cycles of foraging bacteria through changes in metabolism and motility

A. K. M. Stubbusch, J. M. Keegstra, J. Schwartzman, S. Pontrelli, E. E. Clerc, S. Charlton, R. Stocker, C. Magnabosco, O. T. Schubert, M. Ackermann, G. G. D'Souza

This study shows that marine bacteria switch from polysaccharide degradation to motility when exposed to breakdown products, enabling dispersal to new nutrient sources.

bioRxiv · Jul 14, 2023Microbiology

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

K. R. Bewley, K. E. R. Gooch, K. M. Thomas, S. R. Longet, N. Wiblin, L. Hunter, K. Chan, P. Brown, R. A. Russell, C. Ho, G. Slack, H. E. Humphries, L. Alden, L. Allen, M. Aram, , M. Carroll

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

bioRxiv · Dec 21, 2020Pathology

Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

K. A. Ryan, K. R. Bewley, S. A. Fotheringham, P. Brown, Y. Hall, A. C. Marriott, J. A. Tree, L. Allen, M. J. Aram, E. Brunt, K. R. Buttigieg, B. E. Cavell, D. P. Carter, R. Cobb, N. S. Coombes, , M Dennis

This study investigates the dose-dependent response of ferrets to SARS-CoV-2 infection, showing protection against re-challenge and mild clinical disease.

bioRxiv · May 29, 2020Microbiology