Specific interactions with phospho-Ubls and allosteric conformational changes regulate the E3 ligase activity of Parkin
D. R. Lenka, S. Chaurasiya, A. Kumar
This study determines the crystal structure of Parkin bound with phospho-NEDD8, revealing how phospho-Ubls and conformational changes regulate Parkin's E3 ligase activity.
bioRxiv · Nov 21, 2023 · PreprintBiochemistry