Author

A. G. Freud

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

B. Knott· 2 shared D. Epstein· 2 shared E. Grunstein· 2 shared E. M. Mace· 2 shared E. Wright· 2 shared M. Bell· 2 shared M. E. Greene· 2 shared P. M. Porrett· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

B. Knott

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans

R. Asiimwe, B. Knott, M. E. Greene, E. Wright, M. Bell, D. Epstein, S. D. Yates, M. V. Gonzalez, S. Fry, E. Boydston, S. Clevenger, J. E. Locke, B. E. Brocato, C. M. Burgan, R. Burney, , P. M. Porrett

The paper identifies NFAT inhibition as a cause of reduced uterine natural killer (uNK) cells and pregnancy complications in humans through analysis of uterus transplant recipients.

bioRxiv · Mar 7, 2024 · PreprintImmunology

Sequential Transcriptional Programs of Tissue Residency Drive Human Uterine NK Cell Development

M. E. Greene, R. Asiimwe, E. Wright, M. Bell, D. Epstein, S. D. Yates, B. Knott, S. Fry, S. Clevenger, J. Locke, S. C. Little, H. Richter, A. G. Freud, P. M. Porrett

This study identifies sequential transcriptional programs of tissue residency driving human uterine NK cell development through single-cell analyses.

bioRxiv · Feb 29, 2024 · PreprintImmunology

Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry & high-resolution microscopy

E. Hegewisch-Solloa, J. E. Melsen, H. Ravichandran, A. Rendeiro, B. Mundy-Bosse, A. G. Freud, J. C. Melms, S. E. Eisman, B. Izar, E. Grunstein, T. J. Connors, O. Elemento, A. Horowitz, E. M. Mace

This study maps human natural killer cell development in pediatric tonsil using imaging mass cytometry and high-resolution microscopy, revealing stage-specific localization and interactions.

bioRxiv · Sep 5, 2023 · PreprintImmunology

Aiolos modulates the TFH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25

K. A. Read, D. M. Jones, S. Pokhrel, E. D. S. Hales, A. Varkey, J. A. Tuazon, C. D. Eisele, O. Abdouni, A. Saadey, R. T. Warren, M. D. Powell, J. M. Boss, E. A. Hemann, J. S. Yount, H. E. Ghoneim, , K. J. Oestreich

This study identifies Aiolos as a regulator of TFH and CD4-CTL differentiation, showing it modulates the Zfp831/TCF-1/Bcl-6 axis and suppresses the cytotoxic gene program.

bioRxiv · May 18, 2022 · PreprintImmunology

Differential integrin adhesome expression defines human natural killer cell residency and developmental stage

E. Hegewisch Solloa, S. Seo, B. L. Mundy-Bosse, A. Mishra, E. Waldman, S. Maurrasse, E. Grunstein, T. J. Connors, A. G. Freud, E. M. Mace

This study identifies differences in integrin adhesome expression in human NK cells based on tissue location and developmental stage, linking these differences to cortical actin homeostasis.

bioRxiv · Dec 1, 2020Cell Biology

Gut Dysbiosis with a Pathobiont Shifts the Intestinal Microbiota Profile and Accelerates Lupus Nephritis

G. R. Valiente, A. Munir, M. L. Hart, P. Blough, T. T. Wada, E. E. Dalan, W. L. Willis, L.-C. Wu, A. G. Freud, W. N. Jarjour

This study shows that colonizing NZM2410 mice with Segmented Filamentous Bacteria (SFB) worsens lupus nephritis by increasing intestinal dysbiosis and promoting kidney inflammation.

bioRxiv · Oct 12, 2020 · PreprintImmunology