S. E. Jacobsen

MBD2 couples DNA methylation to Transposable Elements silencing during male gametogenesis.

This study identifies MBD2 as a methyl reader that silences transposable elements during male gametogenesis by acting downstream of DNA methylation.

ACD15, ACD21, and SLN regulate accumulation and mobility of MBD6 to silence genes and transposable elements.

The paper shows ACD15 and ACD21 are essential for MBD5/6 complex accumulation and mobility, which silences genes and transposable elements in Arabidopsis.

H1 restricts euchromatin-associated methylation pathways from heterochromatic encroachment

This study shows H1 restricts RdDM from encroaching into heterochromatin, maintaining genomic boundaries through chromatin compaction and preventing methylation gains.

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

This study shows TRB proteins recruit JMJ14 to demethylate H3K4me3 and coordinate with PRC2 to repress target genes.

The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.

The paper shows MOM1 recruits RdDM machinery via MORC6 to establish de novo DNA methylation and maintain chromatin state at RdDM sites.

MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions

The paper investigates RdDM-independent functions of MORC proteins, showing they compact chromatin and repress gene expression by reducing TF accessibility, especially under stress.

A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis

The paper identifies multiple proteins that can silence genes in Arabidopsis through various epigenetic mechanisms and develops a machine learning model to predict silencing efficacy.

Genome editing in plants using the compact editor Cas{Phi}

This paper demonstrates that the hypercompact Cas{Phi} nuclease can generate heritable gene edits in Arabidopsis with high specificity and efficiency, and shows that its performance is influenced by chromatin environment and temperature.

Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis

This study shows that ASF1 in Arabidopsis preferentially interacts with the HIRA complex for H3.3-H4 deposition, affecting chromatin structure and gene regulation.

Haplotype resolved DNA methylome of African cassava genome

This study presents a haplotype-resolved DNA methylome of the African cassava genome using long-read sequencing and chromosomal conformation capture techniques.

Mutations in DNA polymerase δ subunit 1 mediate CMD2-type resistance to Cassava Mosaic Geminiviruses

The paper identifies a nonsynonymous SNP in MePOLD1 as the causal mutation for CMD2-type resistance to Cassava Mosaic Geminiviruses, validated through virus-induced gene silencing and allele analysis.

Improving cassava bacterial blight resistance by editing the epigenome

This study edits the epigenome of cassava to improve resistance to bacterial blight by blocking a susceptibility gene's activation.

The plant mobile domain proteins MAIN and MAIL1 interact with the phosphatase PP7L to regulate gene expression and silence transposable elements in Arabidopsis thaliana.

The paper identifies an interaction between PMD proteins MAIN and MAIL1 with the phosphatase PP7L that regulates gene expression and silences transposable elements in Arabidopsis thaliana.