Author

S. E. W. Jacobsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:clustering· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

P. S. Woll· 3 shared A. J. Mead· 2 shared A. Castor· 1 shared A. Hamblin· 1 shared A. Ho· 1 shared A. L. Chedeville· 1 shared A. M. Lord· 1 shared A. Marciniak-Czochra· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

P. S. Woll

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Erythroid differentiation intensifies RNA mis-splicing in SF3B1-mutant myelodysplastic syndromes with ring sideroblasts

P. L. Moura, T. Mortera-Blanco, I. J. F. Hofman, G. Todisco, W. W. Kretzschmar, A.-C. Bjorklund, M. Creignou, M. Hagemann-Jensen, C. Ziegenhain, D. C. Granados, I. Barbosa, G. Walldin, M. Jansson, N. Ashley, A. J. Mead, , E. Hellstrom-Lindberg

This study investigates SF3B1-mutant myelodysplastic syndromes with ring sideroblasts by isolating RS and analyzing their development and mis-splicing during erythroid differentiation.

bioRxiv · Apr 11, 2023Cancer Biology

Parallel clonal and molecular profiling of hematopoietic stem cells using RNA barcoding

E. E. Wojtowicz, J. Mistry, V. Uzun, A. Scoones, D. V. Chin, L. Kettyle, F. Grasso, A. M. Lord, G. Etherington, C. Hellmich, P. S. Woll, M. E. Belderbos, K. M. Bowles, C. Nerlov, W. Haerty, , I. C. Macaulay

This study uses RNA barcoding and single-cell RNA-seq to analyze clonal dynamics of hematopoietic stem cells, showing that platelet depletion shifts HSC output to platelets and new myeloid clones.

bioRxiv · May 16, 2022 · PreprintCell Biology

Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics

A. Rodriguez-Meira, R. Norfo, W. X. Wen, A. L. Chedeville, H. Rahman, J. OSullivan, G. Wang, E. Louka, W. Kretzschmar, A. Paterson, C. Brierley, J.-E. Martin, C. Demeule, M. Bashton, N. Sousos, , A. J. Mead

The paper uses single-cell multi-omic analysis to study TP53-mutant cancer evolution in leukaemia, identifying a role for chronic inflammation in promoting TP53 mutant clones.

bioRxiv · Mar 28, 2022 · PreprintCancer Biology

Complex genotype-phenotype relationships shape the response to treatment of Down Syndrome Childhood Acute Lymphoblastic Leukaemia

C. Lutz, V. A. Turati, R. Clifford, P. S. Woll, T. Stiehl, A. Castor, S. A. Clark, H. Ferry, V. Buckle, A. Trumpp, A. Ho, A. Marciniak-Czochra, J. Herrero, A. Schuh, S. E. W. Jacobsen, T. Enver

This study investigates genotype-phenotype relationships in Down Syndrome ALL, showing that genetic and phenotypic heterogeneity influences treatment response and relapse through clonal competition.

bioRxiv · Feb 6, 2022Cancer Biology