Author

S. Fonseca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 4 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:Arabidopsis· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

V. Rubio· 4 shared C. Bourbousse· 3 shared E. Canibano· 3 shared F. Barneche· 2 shared M. Garcia-Leon· 2 shared A. Genovesio· 1 shared A. Lopez-Perrote· 1 shared A. Nassrallah· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersPlant Biology

V. Rubio

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Author profile →

6 papers

Recent·Most cited

The structure of the R2T complex reveals a different architecture of the related HSP90 co-chaperones R2T and R2TP

A. Palacios-Abella, A. Lopez-Perrote, J. Boskovic, S. Fonseca, C. Urbez, V. Rubio, O. Llorca, D. Alabadi

The paper determines the cryoEM structure of the Arabidopsis R2T complex, revealing its dodecameric organization and distinct architecture compared to the human R2TP complex.

bioRxiv · Mar 27, 2024 · PreprintBiochemistry

An active light signalling pathway is necessary for ABA-induced inhibition of hypocotyl elongation.

E. Canibano, D. Gomez-Soto, J. C. Oliveros, C. Bourbousse, S. Fonseca

This study shows that an active light signaling pathway is necessary for ABA-induced inhibition of hypocotyl elongation in light-grown seedlings, but not in dark-grown etiolated seedlings.

bioRxiv · Jan 20, 2024 · PreprintPlant Biology

COP1 promotes seed germination by destabilizing RGA-LIKE2 (RGL2) in Arabidopsis

B.-D. Lee, Y. Yim, E. Canibano, S.-H. Kim, M. Garcia-Leon, V. Rubio, S. Fonseca, N.-C. Paek

The paper identifies COP1 as an upstream negative regulator of RGL2, showing COP1 promotes seed germination by ubiquitinating and destabilizing RGL2 in Arabidopsis.

bioRxiv · Dec 1, 2021 · PreprintPlant Biology

Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages

N. Kriplani, S. M. R. Clohisey, S. Fonseca, S. Fletcher, H.-M. Lee, J. Ashworth, D. Kurian, S. J. Lycett, C. Tait-Burkard, J. K. Baillie, M. E. J. Woolhouse, S. R. Carding, J. P. Stewart, P. Digard

This study shows that SARS-CoV-2 ORF8 protein modulates cytokine expression in human macrophages, with sequence polymorphisms affecting IL-6 and IL-8 secretion.

bioRxiv · Aug 13, 2021 · PreprintMicrobiology

DET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis

E. Canibano, C. Bourbousse, M. Garcia-Leon, L. Wolff, C. Garcia-Baudino, F. Barneche, V. Rubio, S. Fonseca

This study shows DET1 stabilizes COP1 to reduce HY5 protein levels, preventing HY5 from over-activating second-site targets and causing hyper-photomorphogenic phenotypes.

bioRxiv · Sep 30, 2020Plant Biology

DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

A. Nassrallah, M. Rougee, C. Bourbousse, S. Drevensek, S. Fonseca, E. Iniesto, O. Ait-Mohamed, A.-F. Deton-Cabanillas, G. Zabulon, I. Ahmed, D. Stroebel, V. Masson, B. Lombard, D. Eeckhout, K. Gevaert, , F. Barneche

The paper shows DET1 regulates H2Bub homeostasis in Arabidopsis by controlling the stability of a DUBm through interaction with DDA1.

bioRxiv · Apr 30, 2018Plant Biology