S. Geley

Identification of a link between splicing and endoplasmic reticulum proteostasis

This study identifies SNRPB as a regulator of ER export and links it to osteogenesis and CCMS through its effects on splicing and the UPR.

Chronic deregulation of the spindle assembly checkpoint triggers myelosuppression and gastrointestinal atrophy

The paper investigates the effects of chronic SAC activation in mice, finding it causes bone marrow aplasia and intestinal atrophy, with BIM playing a critical role in gastrointestinal cell death.

Mechanical strain stimulates COPII-dependent trafficking via Rac1

The paper shows mechanical strain regulates COPII-dependent ER-export through Rac1-mediated mechanotransduction.

Migrating lung monocytes internalize and inhibit growth of Aspergillus fumigatus conidia

The paper identifies CD43+ monocytes in rat lungs that internalize and inhibit Aspergillus fumigatus conidia, suggesting a role in local antifungal defense.

Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

This study identifies four kinesins that coordinate to drive microtubule poleward flux in human cells, which is essential for regulating spindle size during mitosis.

Zebrafish Gpr161 contributes to basal hedgehog repression in a tissue-specific manner

This study shows that Gpr161 contributes to tissue-specific basal repression of Hedgehog signaling in zebrafish by modulating PKA activity in the neural tube and myotome.