Author

S. Hafenstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. R. Parrish· 2 shared E. C. Holmes· 2 shared H. Lee· 2 shared I. E. H. Voorhees· 2 shared L. B. Goodman· 2 shared R. Lopez-Astacio· 2 shared A. B. Allison· 1 shared A. Roder· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersEvolutionary Biology

C. R. Parrish

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirus

R. Lopez-Astacio, O. F. Adu, D. J. Goetschius, H. Lee, W. Weichert, B. R. Wasik, S. P. Frueh, B. K. Alford, I. E. H. Voorhees, J. F. Flint, S. Saddoris, L. B. Goodman, E. C. Holmes, S. Hafenstein, C. R. Parrish

This study uses in vitro selection and deep sequencing to identify escape mutations in canine parvovirus selected by two antibodies, revealing mechanisms of antibody and receptor binding interactions.

Journal of Virology · Jun 29, 2023Peer-reviewedEvolutionary Biology

Accurate Virus Identification with Interpretable Raman Signatures by Machine Learning

J. Ye, Y.-T. Yeh, Y. Xue, Z. Wang, N. Zhang, H. Liu, K. Zhang, Z. Yu, A. Roder, N. P. Lopez, L. Organtini, W. Greene, S. Hafenstein, H. Lu, E. Ghedin, , S. X. Huang

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

bioRxiv · Jun 4, 2021Biophysics

Everything you wanted to know about Mayaro virus but were afraid to ask: Characterization and lifecycle of Mayaro virus in vertebrate and invertebrate cellular backgrounds

S. Pujhari, M. Brustolin, C. C. Heu, R. Smithwick, M. Larrosa, S. Hafenstein, J. L. Rasgon

This study characterizes the replication, entry mechanisms, and pathogenesis of Mayaro virus in vertebrate and invertebrate cells, identifying pH-dependent endocytosis and macropinocytosis as entry routes and cytopathic effects associated with apoptosis.

bioRxiv · Nov 18, 2020 · PreprintMicrobiology

Limited intra-host diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread

I. E. H. Voorhees, H. Lee, A. B. Allison, R. Lopez-Astacio, L. B. Goodman, O. O. Oyesola, O. Omobowale, O. Fagbohun, E. J. Dubovi, S. Hafenstein, E. C. Holmes, C. R. Parrish

This study analyzes 40 years of canine parvovirus evolution, finding limited intra-host diversity and slow genetic change despite its adaptability.

bioRxiv · Jul 25, 2019Evolutionary Biology