W. Weichert

Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirus

This study uses in vitro selection and deep sequencing to identify escape mutations in canine parvovirus selected by two antibodies, revealing mechanisms of antibody and receptor binding interactions.

Transcriptionally defined morphological subtypes of pancreatic ductal adenocarcinoma

The paper identifies five transcriptional subtypes of PDAC cells with distinct morphological patterns and confirms their prognostic significance using bulk RNA-sequencing datasets.

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

This study shows that low GATA4 and GATA6 expression in pancreatic ductal adenocarcinoma (PDAC) is linked to worse patient outcomes and loss of the classical tumor phenotype.

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

Influenza A viruses serially passaged in different MDCK cell lines exhibit limited sequence variation across their genomes, with the exception of the hemagglutinin gene

This study passaged influenza A viruses in different MDCK cell lines and found limited genome-wide sequence variation, with most mutations occurring in the hemagglutinin gene.

Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation

This study analyzes influenza A virus evolution in mice during serial passage, finding varied mutation patterns and no clear adaptive evolution or sialic acid-related sequence differences.

Multi-task learning of a deep k-nearest neighbour network for histopathological image classification and retrieval

This paper introduces a multi-task deep learning framework for histopathological image classification and retrieval using k-nearest neighbors to improve interpretability.

Expression of 9-O- and 7,9-O-acetyl modified sialic acids in cells and their effects on influenza viruses

The paper examines the expression and effects of 9-O- and 7,9-O-acetyl modified sialic acids on influenza virus infections in human and canine cells.

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC

The paper identifies an APOBEC-enriched subgroup of HPV-negative HNSCC with distinct immunogenic features linked to immune evasion and potential response to immunotherapy.