Author

S. Handa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

P. Ghosh· 4 shared A. J. Borst· 1 shared A. McGuire· 1 shared A. Reyna· 1 shared A. Wall· 1 shared B. Fiala· 1 shared B. G. Paul· 1 shared B. L. Stoddard· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiochemistry

P. Ghosh

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Author profile →

5 papers

Recent·Most cited

Structural Requirements for Reverse Transcription by a Diversity-generating Retroelement

S. Handa, T. Biswas, J. Chakraborty, G. Ghosh, B. G. Paul, P. Ghosh

This study identifies how surrounding RNA structures facilitate reverse transcription in DGRs by positioning an RNA homoduplex for cis-priming and regulating mutagenesis.

bioRxiv · Oct 23, 2023Microbiology

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

H. Malhi, L. J. Homad, Y.-H. Wan, B. Poudel, B. Fiala, A. J. Borst, J. Y. Wang, C. Walkey, J. Price, A. Wall, S. Singh, Z. Moodie, S. Handa, C. Correnti, B. L. Stoddard, , A. McGuire

This study evaluates a nanoparticle vaccine displaying EBV gH/gL, showing it protects humanized mice against lethal EBV challenge, while monomeric gH/gL does not.

bioRxiv · Feb 17, 2022Immunology

Determinants of Adenine-mutagenesis in Diversity-Generating Retroelements

S. Handa, A. Reyna, T. Wiryaman, P. Ghosh

This study identifies key determinants of adenine-mutagenesis in a DGR system by analyzing the catalytic efficiency of the bRT-Avd complex.

bioRxiv · Apr 29, 2020Biochemistry

Crystal structure of a Thermus aquaticus diversity-generating retroelement variable protein

S. Handa, K. L. Shaw, P. Ghosh

The paper reports the crystal structure of a thermostable DGR variable protein from Thermus aquaticus and confirms its CLec-fold structure, supporting its potential for molecular display applications.

bioRxiv · Oct 1, 2018Biochemistry

Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex

S. Handa, Y. Jiang, S. Tao, R. Foreman, R. Schinazi, J. F. Miller, P. Ghosh

The paper demonstrates that the DGR reverse transcriptase and Avd protein complex selectively mutagenize adenines during cDNA synthesis from DGR RNA templates.

bioRxiv · Jun 26, 2018Biochemistry