Author

S. J. Brouns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 3 Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

F. L. Nobrega· 4 shared A. R. Costa· 2 shared B. Estrada Bonilla· 2 shared P.-J. Haas· 2 shared A. Böttger· 1 shared A. C. Fluit· 1 shared A. C. Haagsma· 1 shared A. Makaya· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

F. L. Nobrega

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Accumulation of defense systems in phage resistant strains of Pseudomonas aeruginosa

A. R. Costa, D. F. van den Berg, J. Q. Esser, A. Muralidharan, H. van den Bossche, B. Estrada Bonilla, B. A. van der Steen, A. C. Haagsma, A. C. Fluit, F. L. Nobrega, P.-J. Haas, S. J. Brouns

The paper shows that Pseudomonas aeruginosa strains with more phage defense systems are more resistant to phages, and these systems often target different phage genera.

bioRxiv · Aug 12, 2022 · PreprintMicrobiology

Class I DISARM provides anti-phage and anti-conjugation activity by unmethylated DNA recognition

C. Aparicio-Maldonado, G. Ofir, A. Salini, R. Sorek, F. L. Nobrega, S. J. Brouns

This study identifies Class 1 DISARM as a system providing anti-phage and anti-conjugation activity through recognition of unmethylated DNA sites.

bioRxiv · Dec 28, 2021 · PreprintMicrobiology

Structural basis for broad anti-phage immunity by DISARM

J. P. Bravo, C. A. Maldonado, F. L. Nobrega, S. J. Brouns, D. W. Taylor

This study determines the cryo-EM structures of the DISARM complex DrmAB and elucidates its mechanism of phage DNA recognition and activation.

bioRxiv · Dec 26, 2021Biochemistry

Genomic characterization of four novel bacteriophages infecting the clinical pathogen Klebsiella pneumoniae

B. Estrada Bonilla, A. R. Costa, T. van Rossum, S. Hagedoorn, H. Walinga, M. Xiao, W. Song, P.-J. Haas, F. L. Nobrega, S. J. Brouns

The paper isolates and sequences four novel bacteriophages infecting Klebsiella pneumoniae, revealing low sequence identity to known phages and potential new DNA packaging mechanisms and protein clades.

bioRxiv · Mar 2, 2021Microbiology

Iron can be microbially extracted from Lunar and Martian regolith simulants and 3D printed into tough structural materials

S. M. Castelein, T. F. Aarts, J. Schleppi, R. Hendrikx, A. Böttger, D. Benz, M. Marechal, A. Makaya, S. J. Brouns, M. Schwentenwein, A. S. Meyer, B. A. E. Lehner

This paper demonstrates using bacteria to extract iron from lunar and Martian regolith simulants and 3D printing the extracted material into stronger structural components.

bioRxiv · Nov 15, 2020Microbiology