Author

S. J. Cleary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

M. R. Looney· 2 shared Y. Seo· 2 shared A. E. Bentlage· 1 shared A. Mackinnon· 1 shared B. Gooptu· 1 shared C. Conrad· 1 shared C. Harris· 1 shared C. J. Hitchman· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

M. R. Looney

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Author profile →

3 papers

Recent·Most cited

IgG hexamers initiate acute lung injury

S. J. Cleary, Y. Seo, J. J. Tian, N. Kwaan, D. P. Bulkley, A. E. Bentlage, G. Vidarsson, E. Boilard, R. Spirig, J. C. Zimring, M. R. Looney

This study shows that IgG hexamerization is critical for triggering acute lung injury and suggests therapeutic strategies targeting hexamer formation.

bioRxiv · Jan 24, 2024Immunology

Optimizing anesthesia and delivery approaches for dosing into lungs of mice

Y. Seo, L. Qiu, M. Magnen, C. Conrad, S. F. Moussavi-Harami, M. R. Looney, S. J. Cleary

This study compares pulmonary dosing efficiency in mice under different anesthetic and delivery methods, finding that ketamine/xylazine anesthesia and oropharyngeal aspiration improve lung delivery compared to isoflurane and intranasal dosing.

bioRxiv · Feb 1, 2023Physiology

CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis

P. Stylianou, S. Rushwan, W. Wang, M. A. Miah, O. Darweesh, A. Mackinnon, K. M. Roach, C. J. Hitchman, O. Gonchar, S. Thorpe, C. Harris, R. Haigh, D. F. Richards, V. Snetkov, J. Beasley, , B. Gooptu

This study identifies CD98 as critical for inflammatory responses to injury stimuli in IPF exacerbations and COVID pneumonitis, showing its role in IL-6 and IL-8 responses and fibrosis progression.

bioRxiv · Aug 12, 2022 · PreprintCell Biology