Optimizing anesthesia and delivery approaches for dosing into lungs of mice
Y. Seo, L. Qiu, M. Magnen, C. Conrad, S. F. Moussavi-Harami, M. R. Looney, S. J. Cleary
This study compares pulmonary dosing efficiency in mice under different anesthetic and delivery methods, finding that ketamine/xylazine anesthesia and oropharyngeal aspiration improve lung delivery compared to isoflurane and intranasal dosing.
bioRxiv · Feb 1, 2023Physiology