Author

M. R. Looney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

M. Magnen· 3 shared A. A. Rao· 2 shared C. M. Hendrickson· 2 shared D. J. Erle· 2 shared K. H. Hu· 2 shared L. Rodriguez· 2 shared M. F. Krummel· 2 shared P. G. Woodruff· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

M. Magnen

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Author profile →

4 papers

Recent·Most cited

IgG hexamers initiate acute lung injury

S. J. Cleary, Y. Seo, J. J. Tian, N. Kwaan, D. P. Bulkley, A. E. Bentlage, G. Vidarsson, E. Boilard, R. Spirig, J. C. Zimring, M. R. Looney

This study shows that IgG hexamerization is critical for triggering acute lung injury and suggests therapeutic strategies targeting hexamer formation.

bioRxiv · Jan 24, 2024Immunology

Optimizing anesthesia and delivery approaches for dosing into lungs of mice

Y. Seo, L. Qiu, M. Magnen, C. Conrad, S. F. Moussavi-Harami, M. R. Looney, S. J. Cleary

This study compares pulmonary dosing efficiency in mice under different anesthetic and delivery methods, finding that ketamine/xylazine anesthesia and oropharyngeal aspiration improve lung delivery compared to isoflurane and intranasal dosing.

bioRxiv · Feb 1, 2023Physiology

Immediate myeloid depot for SARS-CoV-2 in the human lung

M. Magnen, R. You, A. A. Rao, R. T. Davis, L. Rodriguez, C. R. Simoneau, L. Hysenaj, K. H. Hu, The UCSF COMET Consortium, C. Love, P. G. Woodruff, D. J. Erle, C. M. Hendrickson, C. S. Calfee, M. A. Matthay, , M. R. Looney

The paper investigates early SARS-CoV-2 infection in human lung myeloid cells, finding rapid viral tropism, ACE2 dependence, and poor interferon induction, suggesting a myeloid depot for viral persistence.

bioRxiv · Apr 28, 2022Immunology

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

A. J. Combes, T. Courau, N. F. Kuhn, K. H. Hu, A. Ray, W. S. Chen, S. J. Clearly, N. W. Chew, D. Kushnoor, G. C. Reeder, A. Shen, J. Tsui, K. J. Hiam-Galvez, P. Munoz-Sandoval, W. S. Zhu, , M. F. Krummel

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

bioRxiv · Oct 28, 2020Immunology