Author

S. Karambelkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

J. Bondy-Denomy· 2 shared A. Oromi-Bosch· 1 shared A. R. Davidson· 1 shared B. A. Osuna· 1 shared B. Garcia· 1 shared B. P. Kleinstiver· 1 shared C. Mahendra· 1 shared G. Swapna· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

J. Bondy-Denomy

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Author profile →

3 papers

Recent·Most cited

RNA targeting with CRISPR-Cas13a facilitates bacteriophage genome engineering

J. Guan, A. Oromi-Bosch, S. D. Mendoza, S. Karambelkar, J. Berry, J. Bondy-Denomy

This paper develops a CRISPR-Cas13a-based method to edit bacteriophage genomes, enabling precise gene modifications and functional studies of phage genes.

bioRxiv · Feb 14, 2022 · PreprintMicrobiology

Emergence of a novel immune-evasion strategy from an ancestral protein fold in bacteriophage Mu

S. Karambelkar, S. Udupa, V. N. Gowthami, S. G. Ramachandra, G. Swapna, V. Nagaraja

This paper identifies acetyl CoA and iron as essential for the methylcarbamoylation of phage Mu DNA, revealing a novel mechanism involving Fe-S cluster-mediated free radical chemistry.

bioRxiv · Dec 2, 2019Biochemistry

Listeria phages induce Cas9 degradation to protect lysogenic genomes

B. A. Osuna, S. Karambelkar, C. Mahendra, K. A. Christie, B. Garcia, A. R. Davidson, B. P. Kleinstiver, S. Kilcher, J. Bondy-Denomy

This study identifies AcrIIA1 as a phage-encoded protein that inhibits Cas9 in Listeria monocytogenes by promoting its degradation, protecting lysogenic genomes.

bioRxiv · Sep 30, 2019Microbiology