Author

S. Kilcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

M. J. Loessner· 4 shared J. Baggenstos· 3 shared C. I. Matter· 2 shared J. Du· 2 shared L. Hunold· 2 shared L. Leitner· 2 shared M. Dunne· 2 shared P. Piffaretti· 2 shared

Activity by Year

2016-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

M. J. Loessner

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CRISPR-Cas9 enables efficient genome engineering of the strictly lytic, broad host-range staphylococcal bacteriophage K

J. Fernbach, J. Baggenstos, J. Riedo, S. McCallin, M. J. Loessner, S. Kilcher

This paper develops a CRISPR-Cas9-based platform for engineering Twortvirinae phages to create reporter phages for detecting Staphylococcus aureus in clinical and environmental samples.

bioRxiv · Mar 19, 2024Bioengineering

Engineered reporter phages for rapid detection of Escherichia coli, Klebsiella spp., and Enterococcus spp. in urine

S. Meile, J. Du, S. Staubli, S. Grossmann, H. Koliwer-Brandl, P. Piffaretti, L. Leitner, C. I. Matter, J. Baggenstos, L. Hunold, S. Milek, C. Guebeli, M. Kozomara-Hocke, V. Neumeier, A. Botteon, , S. Kilcher

This study develops a rapid phage-based diagnostic assay to detect E. coli, Klebsiella spp., and Enterococcus spp. in urine with high sensitivity and specificity within 5 hours.

bioRxiv · Nov 23, 2022 · PreprintMicrobiology

Gram-positive bacteria evade phage predation through endolysin-mediated L-form conversion

J. C. Wohlfarth, M. Feldmueller, A. Schneller, S. Kilcher, M. Burkolter, M. Pilhofer, M. Schuppler, M. J. Loessner

This paper shows Gram-positive bacteria like Listeria monocytogenes and Enterococcus faecalis can evade phage predation by temporarily converting to L-forms, which are wall-deficient but viable cells.

bioRxiv · May 24, 2022 · PreprintMicrobiology

Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors

J. Du, S. Meile, J. Baggenstos, T. Jaeggi, P. Piffaretti, L. Hunold, C. I. Matter, L. Leitner, T. M. Kessler, M. J. Loessner, S. Kilcher, M. Dunne

This paper develops heterologous effector phage therapeutics (HEPTs) to enhance bacteriophage treatment of UTIs by delivering colicin-like effectors that suppress resistance and improve bacterial killing.

bioRxiv · Mar 9, 2022 · PreprintBioengineering

Listeria phages induce Cas9 degradation to protect lysogenic genomes

B. A. Osuna, S. Karambelkar, C. Mahendra, K. A. Christie, B. Garcia, A. R. Davidson, B. P. Kleinstiver, S. Kilcher, J. Bondy-Denomy

This study identifies AcrIIA1 as a phage-encoded protein that inhibits Cas9 in Listeria monocytogenes by promoting its degradation, protecting lysogenic genomes.

bioRxiv · Sep 30, 2019Microbiology

Proteotype profiling unmasks a viral signaling network essential for poxvirus assembly and transcriptional competence

K. Novy, S. Kilcher, U. Omasits, C. K. E. Bleck, C. Beerli, M. Syedbasha, A. Maiolica, J. Mercer, B. Wollscheid

The paper identifies a viral signaling network regulated by F10 kinase and H1 phosphatase through phosphoproteomic analysis, revealing their roles in poxvirus assembly and transcriptional competence.

bioRxiv · Nov 11, 2016Microbiology