S. L. Chen

The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis

This paper shows that HtrA clears off-pathway pili in E. faecalis, leading to membrane stress and antibiotic susceptibility.

Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis

This study shows that depleting cationic lipids in Enterococcus faecalis leads to adaptive lipid remodeling, including reduced PG, increased phosphorus-containing lipids, and altered fatty acid metabolism.

Mass allelic exchange: enabling sexual genetics in Escherichia coli

The paper introduces MAE, a method for creating F1 hybrids of E. coli to enable linkage analysis and study phenotypic diversity, including virulence.

Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment

The paper characterizes antibiotic resistance genes and opportunistic pathogens in a hospital environment using genomic sequencing and identifies multidrug-resistant strains persisting for over 8 years.

Comprehensive Identification of Fim-Mediated Inversions in Uropathogenic Escherichia coli with Structural Variation Detection Using Relative Entropy

The paper identifies fim-mediated inversions in UPEC using SVRE, finding no new Fim recombinase-regulated switches beyond previously known ones.