K. A. Kline

Bosutinib stimulates macrophage survival, phagocytosis and intracellular killing of bacteria

This paper shows bosutinib enhances macrophage phagocytosis and bacterial killing, reducing infection in mice.

The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis

This paper shows that HtrA clears off-pathway pili in E. faecalis, leading to membrane stress and antibiotic susceptibility.

Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

This study uses scRNA-seq to analyze infected and uninfected wounds in mice, revealing transcriptional and metabolic changes linked to E. faecalis infection and its impact on wound healing.

An essential protease, FtsH, influences daptomycin resistance acquisition in Enterococcus faecalis

This study identifies FtsH as a key factor influencing the speed of daptomycin resistance acquisition in Enterococcus faecalis through its role in regulating HrcA and metabolic processes.

Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis

This study shows that depleting cationic lipids in Enterococcus faecalis leads to adaptive lipid remodeling, including reduced PG, increased phosphorus-containing lipids, and altered fatty acid metabolism.

Mitoxantrone Targets Both Host and Bacteria to Overcome Vancomycin Resistance in Enterococcus faecalis

Mitoxantrone synergizes with vancomycin against vancomycin-resistant Enterococcus faecalis by direct antibiotic activity and enhancing host macrophage recruitment and bactericidal activity.

Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound infection

This study identifies purine biosynthesis and the MptABCD phosphotransferase system as critical for E. faecalis replication and persistence during wound infection, driven by microenvironmental changes.

An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

The paper identifies an RNA modification enzyme in Enterococcus faecalis that senses reactive oxygen species and regulates translation of stress-response proteins.

Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in polymicrobial biofilms

This study shows that Enterococcus faecalis inhibits Pseudomonas aeruginosa growth in iron-restricted biofilms through lactic acid production and pH reduction.

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin

This study shows E. coli kills S. aureus via colibactin and identifies BarA-UvrY as a novel regulator of the pks island involved in this process.

Enterococcus faecalis persists and replicates within epithelial cells in vitro and in vivo during wound infection

This study shows Enterococcus faecalis persists and replicates within epithelial cells in vitro and in vivo during wound infection, using macropinocytosis to avoid lysosomal degradation.

Multiplex CRISPRi-Cas9 silencing of planktonic and stage-specific biofilm genes in Enterococcus faecalis

This paper develops a CRISPRi system in Enterococcus faecalis to silence genes involved in biofilm formation, antibiotic resistance, and essentiality, enabling efficient study of pathogenesis and host interactions.

Enterococcus faecalis manganese exporter MntE alleviates manganese toxicity and is required for mouse gastrointestinal colonization

Combined efficacy of a novel antimicrobial cationic peptide polymer with conventional antibiotics to combat multi-drug resistant pathogens

This study shows that the synthetic cationic peptide CSM5-K5 effectively combats multi-drug resistant bacteria, both alone and in combination with antibiotics, without inducing resistance.

Planktonic interference and biofilm alliance between aggregation substance and endocarditis and biofilm associated pili in Enterococcus faecalis

This study examines the co-expression of aggregation substance (AS) and endocarditis and biofilm-associated pili (Ebp) in Enterococcus faecalis, showing their antagonistic and synergistic effects in planktonic growth and biofilm formation.

Enterococcus faecalis Modulates Immune Activation And Slows Healing During Wound Infection

This study shows that high-dose Enterococcus faecalis infections in mice lead to immune modulation, bacterial persistence, and delayed wound healing.