K. K. L. Chong

The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis

This paper shows that HtrA clears off-pathway pili in E. faecalis, leading to membrane stress and antibiotic susceptibility.

An essential protease, FtsH, influences daptomycin resistance acquisition in Enterococcus faecalis

This study identifies FtsH as a key factor influencing the speed of daptomycin resistance acquisition in Enterococcus faecalis through its role in regulating HrcA and metabolic processes.

Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis

This study shows that depleting cationic lipids in Enterococcus faecalis leads to adaptive lipid remodeling, including reduced PG, increased phosphorus-containing lipids, and altered fatty acid metabolism.

Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound infection

This study identifies purine biosynthesis and the MptABCD phosphotransferase system as critical for E. faecalis replication and persistence during wound infection, driven by microenvironmental changes.

Enterococcus faecalis and Staphylococcus aureus mixed species infection attenuates pathogen-specific neutrophil responses and impairs bacterial clearance

This study shows that E. faecalis and S. aureus co-infection reduces neutrophil responses, enhancing survival of both pathogens through immune suppression.

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin

This study shows E. coli kills S. aureus via colibactin and identifies BarA-UvrY as a novel regulator of the pks island involved in this process.

Enterococcus faecalis persists and replicates within epithelial cells in vitro and in vivo during wound infection

This study shows Enterococcus faecalis persists and replicates within epithelial cells in vitro and in vivo during wound infection, using macropinocytosis to avoid lysosomal degradation.

Enterococcus faecalis manganese exporter MntE alleviates manganese toxicity and is required for mouse gastrointestinal colonization

Enterococcus faecalis Promotes Innate Immune Suppression And Polymicrobial Catheter-Associated Urinary Tract Infection

This study shows E. faecalis suppresses macrophage NF-κB signaling and promotes polymicrobial CAUTI by enhancing E. coli infection.

Enterococcus faecalis Modulates Immune Activation And Slows Healing During Wound Infection

This study shows that high-dose Enterococcus faecalis infections in mice lead to immune modulation, bacterial persistence, and delayed wound healing.