Author

P. L. Boutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:zebrafish· 1

Frequent Co-Authors

B. J. Abraham· 1 shared C. G. Ludwig· 1 shared C. L. Kielkopf· 1 shared C. Wu· 1 shared D. Liu· 1 shared E. Glasser· 1 shared J. Galardi· 1 shared J. L. Jenkins· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

B. J. Abraham

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A UHM - ULM interface contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

J. Galardi, V. N. Bela, N. Jeffery, X. He, E. Glasser, S. Loerch, J. L. Jenkins, M. J. Pulvino, P. L. Boutz, C. L. Kielkopf

This study determines the crystal structure of the U2AF2 UHM-SF3B1 ULM interface and shows its role in pre-mRNA splicing and co-regulation with SF1.

bioRxiv · Jan 9, 2022Biochemistry

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

M. L. Insco, B. J. Abraham, S. J. Dubbury, S. Dust, C. Wu, K. Y. Chen, D. Liu, C. G. Ludwig, S. Bellaousov, T. Fabo, T. Henriques, K. Adelman, M. Geyer, P. A. Sharp, R. A. Young, , L. I. Zon

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

bioRxiv · Nov 5, 2019Biophysics